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Publications

, Gordon Fiona, Stein Robin, Howard Mark,

RSC Medicinal Chemistry Vol 17, pp. 1550-1558 (2026)

, Brady Daniel J, , ,

ACS Applied Bio Materials Vol 8, pp. 6854-6864 (2025)

Omale Simeon, Aguiyi John C, , Madaki Aboi JK, Alemika Taiwo E, Johnson Titilayo O, Luka Pam D, Nyam Chuwang J, Nnadi Nnaemeka E, Agwom Francis M, Ohaeri Uchechukwu, Ochala Sunshine O, Clement Patricia T,

Pharmacological Research - Natural Products Vol 7 (2025)

, Matthew Saphia A L, Brady Daniel J, , ,

ACS Biomaterials Science & Engineering Vol 11, pp. 1847–1856 (2025)

Alniss Hasan Y, Kemp Bryony M, Holmes Elizabeth, Hoffman Joanna, Ploch Rafal M, Ramadan Wafaa S, Msallam Yousef A, Al-Jubeh Hadeel M, Madkour Moustafa M, , , El-Awady Raafat,

Bioorganic Chemistry Vol 148 (2024)

Knight Nathan M L, Thompson James D F, , , ,

Advanced Synthesis and Catalysis Vol 366, pp. 2577-2586 (2024)

Teaching

John teaches NMR spectroscopy to third year undergraduate Chemistry students and Biomolecular, Structure, Dynamics and Mechanism to final year Chemistry with Drug Discovery and postgraduate diploma in Medicinal Chemistry. He also delivers a course in NMR spectroscopy to postgraduate researchers.

Research Interests

Research interests include understanding the factors that drive molecular recognition and assembly in biomolecular systems, exploring enzyme reactivity and substrate demand in the context of complex natural product mixtures, defining applications for new experimental developments in the field of NMR spectroscopy, monitoring chemical and biochemical reaction processes and in understanding molecular structure, dynamics and mechanism in the broadest sense.

Professional Activities

Participant

20/5/2025

Peer reviewer

8/11/2023

Examiner

19/10/2023

Chair

9/7/2023

Speaker

17/5/2023

Examiner

20/9/2022

Projects

Parkinson, John (Principal Investigator) Burley, Glenn (Co-investigator) Dufès, Christine (Co-investigator) Irving, Craig (Co-investigator) Jamieson, Craig (Co-investigator) Scott, Fraser (Co-investigator) Seib, Philipp (Co-investigator) Taladriz Sender, Andrea (Co-investigator)

01-Jan-2023 - 31-Jan-2024

Parkinson, John (Principal Investigator)

A National Network for Applications of High-Field NMR in the Life and Physical Sciences

01-Jan-2018 - 30-Jan-2021

Suckling, Colin (Principal Investigator) Graham, Duncan (Co-investigator) Parkinson, John (Co-investigator)

01-Jan-2012 - 30-Jan-2012

Mills, Andrew (Principal Investigator) Parkinson, John (Co-investigator)

Inorganic semiconductors such as TiO2 are known to generate free radicals when irradiated with UV-visible light in the presence of suitable substrates. This project will explore the chemistry of such radicals with the particular objective of identifying and optimising free radical addition reactions which will be beneficial in organic synthesis. Organic synthesis driven by heterogeneous photocatalysis is environmentally and economically attractive, and has the potential to achieve higher selectivity to desired products than conventional routes. We propose to explore a wide range of free radical addition reactions initiated by the known photo-Kolbe reaction of carboxylic acids over titania surfaces. Reactions showing the most promise will be examined in more detail, using in particular in-situ EPR spectroscopy (to observe the initially generated free radicals), in-situ NMR spectroscopy (to identify intermediates and products), and time resolved optical spectroscopy (to observe short lived species) to determine the reaction pathways. Initial studies will be made with TiO2, but we will also explore improvements in performance by adding metals to enhance hole:electron separation, or nitrogen dopants to achieve visible light activation. Visible light activation will also be attempted with other semiconductors. A crucial component of the project is the design and construction of reactors for scaling up promising reactions to a scale attractive to the pharmaceutical industry. The project team has wide experience in photocatalysis, free radical chemistry, in-situ spectroscopic methods and photocatalytic reactor design and construction. Advice and assistance in selection of target reactions relevant to the pharmaceutical industry is provided by GlaxoSmithKline. A successful outcome of the project could bring about a paradigm shift in technologies for high value organic synthesis.

01-Jan-2010 - 01-Jan-2011